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Dermatologist-recommended ISDIN Melatonik 3-in-1 Night Serum is an advanced overnight treatment designed to support the skin’s natural nighttime renewal process. Formulated with melatonin, bakuchiol (a plant-based retinol alternative), and vitamin C, this powerful serum helps improve the appearance of fine lines, uneven tone, and loss of firmness while restoring radiance and vitality.
Working while you sleep, Melatonik 3-in-1 helps defend against oxidative stress accumulated throughout the day and supports skin recovery during its natural repair cycle. The lightweight oil-serum texture absorbs quickly, leaving skin soft, nourished, and visibly refreshed by morning.
Fine lines and wrinkles
Uneven skin tone
Dull or tired-looking skin
Loss of firmness
Early to advanced signs of aging
Nighttime skin repair
3-in-1 formula: antioxidant + retinol alternative + brightening support
Helps improve visible signs of aging overnight
Lightweight oil-serum texture
Supports skin’s natural nighttime renewal cycle
Leaves skin radiant and well-rested in the morning
Helps reduce the appearance of fine lines and wrinkles
Supports firmer, more elastic-looking skin
Improves skin radiance and tone clarity
Provides antioxidant protection against daily stressors
Helps restore a more youthful, refreshed appearance
Nourishes and replenishes skin overnight
Our dermatology team recommends ISDIN Melatonik 3-in-1 Night Serum for patients seeking an effective nighttime treatment that supports skin renewal without traditional retinol irritation. Its unique combination of melatonin, bakuchiol, and vitamin C helps address multiple signs of aging while supporting overall skin health and recovery.
A powerful antioxidant that helps support the skin’s natural nighttime repair processes and protects against oxidative stress.
A plant-derived retinol alternative that helps improve the appearance of fine lines, wrinkles, and skin firmness without the irritation commonly associated with retinoids.
Helps brighten the complexion, improve skin radiance, and support a more even skin tone.
Helps defend against environmental damage that contributes to premature aging.
Provides lightweight hydration and supports overnight skin comfort and barrier repair.
Apply 3–4 drops to clean, dry skin on the face, neck, and décolleté in the evening. Gently massage until fully absorbed. Use as the last step in your nighttime skincare routine.
Skin feels softer, smoother, and deeply nourished overnight. With continued use, the complexion appears brighter, firmer, and more even, with a noticeable reduction in the appearance of fine lines and fatigue.
Our dermatology team recommends pairing Melatonik with a gentle cleanser and hydrating moisturizer to maximize overnight repair. For best results, use consistently as part of a nightly anti-aging routine and always apply sunscreen during the day.
It helps improve fine lines, wrinkles, uneven tone, dullness, and loss of firmness while supporting overnight skin repair.
No. It contains bakuchiol, a plant-based retinol alternative that provides similar benefits with improved tolerability.
Yes. It is designed for nightly use as part of a regular skincare routine.
Yes. Its retinol alternative formulation is generally well tolerated by sensitive skin types.
It can be used alone or followed by a moisturizer depending on skin type and hydration needs.
SIZE: 30 ml / 1.0 Fl. Oz
Ships within 48 hours · Estimated delivery Jun 20 - Jun 25
US$40
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