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HistoDAOÂ is a patented enzyme formula containing diamine oxidase (DAO)Âthe main enzyme responsible for the degradation of ingested histamine. This enzyme has been clinically tested and found to break down food-derived histamine in the digestive tract. DAO is not absorbed and does not have systemic activity. HistDAO does not manage or address antibody-related or IgE-related food allergies.
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