42 Capsules

(Previously known as Bio Absorb PEA Advanced)

High Strength, Enhanced Absorption PEA For Mild Nerve Pain Combined With Saffron.

• For the relief of mild nerve pain, neuralgia, and compression neuropathy.
• Breaks the pain cycle by targeting drivers of pain amplification, is analgesic and enhances endocannabinoid activity.
• A highly bioavailable form of PEA using the Levagen+™ (LipiSperse®) delivery system, with affron® and vitamin B1.

Palmitoylethanolamide (PEA) is neuroprotective, anti-inflammatory, and analgesic4 due to its endocannabinoid (eCB) action. PEA affects eCB  signalling through peroxisome proliferator-activated receptor alpha (PPAR-α)  activation6and is capable of exerting antiallodynic and anti-hyperalgesia  effects by downmodulating both microglial and mast cell activity which has led to its use for neuropathic pain. Both TRPA1 (transient receptor potential ankyrin 1) and TRPV1 (transient receptor potential vanilloid type 1) are co-expressed in sensory neurons and are implicated in neuropathic pain, hyperalgesia and neural amplification.8Animal studies have shown that a main phytoconstitutent of saffron, safranal, desensitises TRPA1 and PEA desensitises TRPV1. In addition, vitamin B1 deficiency results in neuropathic pain and vitamin B1 was found to significantly reduce dorsal root ganglia neuron excitability in vitro, a provocating factor in central sensitisation of pain.

1 in 5 of chronic pain sufferers have neuropathic pain. Patients presenting inadequate response to drug treatment can partly be explained by the hyperalgesia that is associated with long-term opioid use. PEA and saffron have been found to be safe to use alongside common pain medication in certain individuals*.

Clinical Benefits:

PainX PEA Advanced relieves neuropathic pain, such as sciatica, neuropathies and neuralgia.