A Probiotic To Assist In The Management Of Medically Diagnosed Irritable Bowel Syndrome.

Lactobacillus plantarum?299v has been shown to or may:

• Assist in the management of medically diagnosed IBS.¹
• Reduce occurrence of IBS symptoms including, gastrointestinal pain, discomfort, bloating and excessive gas.²
• Contains clinically proven, extensively researched exclusive probiotic strain?Lactobacillus plantarum?299v.

Clinical Benefits

Around 1 in 5 Australians experience the unpleasant symptoms of IBS at some stage including abdominal pain, mucus in stools, and diarrhoea.¹A randomised, double-blind placebo-controlled trial tested the efficacy of?L.plantarum299v in 40 people with IBS over four weeks. All patients treated with?L.plantarum299v reported significant improvement in stool frequency and complete resolution of their abdominal pain.⁴?An overall improvement in all IBS symptoms were noted in 95% of patients in the treatment group, compared to only 15% in the placebo group (Figure 2).⁵?Another study involving 204 adults with medically diagnosed IBS found significant symptom improvement within 2 to 4 weeks including abdominal bloating, pain and bowel movements.⁵

Defective mucosal intolerance and inflammation:?Disruption of the intestinal barrier can lead to inappropriate inflammatory responses which may occur in IBS. Studies have shown?L.plantarum299v to have an effect on barrier function by decrease in permeability⁷?L.plantarum299v has also been shown to exert antipathogenic activity via the production of antimicrobial compounds and inhibiting pathogen adhesion.⁸

A 2016 randomised control trial shows?L.plantarum?299v reduces salivary cortisol during stress.⁹?Stress is well recognised as a common trigger for IBS impacting gut secretions, motility, sensitivity and intestinal permeability. A 2016 study on 41 students showed a significant difference in salivary cortisol levels after only 10 days of taking 10 billion CFU.¹⁰

L.plantarum299v is an extensively researched probiotic strain having been investigated in at least 140 studies to date, with more than 50 clinical trials.¹¹

DIRECTIONS

Adults and children over 5 years:Take 1 capsule daily.

For severe cases:Take 1 capsule twice daily.