Say goodbye to pesky fleas with Advantus (imidacloprid). This powerful flea treatment provides fast and effective relief. A single dose of Advantus soft chews starts killing adult fleas within one hour and is out of their system in 24 hours.* While it does not prevent fleas, the active ingredient, imidacloprid, is a potent insecticide that works to kill fleas when they bite your dog. When fleas ingest the product, the active ingredient over-stimulates the flea's nervous system and kills the flea. For best results, use Advantus at the first sign of fleas. Follow the label instructions carefully, and keep out of reach of children and pets. For complete directions for use and safety information, see product label. *Qureshi, etal. Parasites & Vectors. 2015. Development of Advantus (imidacloprid) soft chewable tablets for the treatment of Ctenocephalides felis infestations on dogs. 8:407 Advantus is a trademark of Elanco and its affiliates.