In Dungeon Hustle, 2-4 players are archetypal fantasy characters running through a dungeon picking up swords, keys, shields, scrolls and potions. Each item comes in different colors, and to pick them up, you must hustle through a path of dungeon tiles of matching color; once you step on a new color (or a corner space), you pick up the tiles that you had stepped on. If, for example, you start on a red key and move on a path that consists of a red sword, another red key, a red shield, and finally a white sword, you stop on the white sword, then pick up all of the red items, including the one where you started movement. You use these items to fight monsters, fulfill quests, and purchase other items.

Dungeon Hustle includes a few semi-cooperative elements. A character can help give a power to another character, for example, and is then rewarded for doing so. More importantly, you must all work together to stop monsters from escaping the dungeon. After a certain number of monsters escapes, the game ends, and whoever has the most victory points at that time wins.